Houston Astros at Cleveland Guardians
First pitch: Tuesday, April 21, 2026 5:10 PM CDT
Venue: Progressive Field
Houston Astros SP: Ryan Weiss (0-2, ERA 6.75)
Cleveland Guardians SP: Parker Messick (3-0, ERA 1.05)

Houston Astros lineup:
1. Carlos Correa - SS (.275, OPS .734)
2. Yordan Alvarez - DH (.326, OPS 1.215)
3. Jose Altuve - 2B (.281, OPS .834)
4. Christian Walker - 1B (.274, OPS .903)
5. Isaac Paredes - 3B (.221, OPS .697)
6. Cam Smith - RF (.238, OPS .743)
7. Yainer Diaz - C (.194, OPS .491)
8. Brice Matthews - CF (.129, OPS .519)
9. Dustin Harris - LF (.176, OPS .599)

Cleveland Guardians lineup:
1. Steven Kwan - CF (.220, OPS .580)
2. Chase DeLauter - DH (.219, OPS .811)
3. José Ramírez - 3B (.230, OPS .850)
4. Kyle Manzardo - 1B (.182, OPS .502)
5. George Valera - RF (.294, OPS .745)
6. Daniel Schneemann - 2B (.302, OPS .890)
7. Angel Martínez - LF (.262, OPS .729)
8. Austin Hedges - C (.250, OPS .611)
9. Brayan Rocchio - SS (.286, OPS .847)